Pharmacological Effects Prometrium 200 mg:
Active substance Prometrium is progesterone (the hormone of the corpus luteum of ovary). Prometrium when injected into the body contributes to the normal secretory transformation of the endometrium. Potentiates the transition from proliferative phase endometrium in the secretory. In the case of fertilization Prometrium causes changes in the endometrium, which contribute to implantation and embryo development. During pregnancy reduces the contractility and excitability of the myometrium and fallopian tubes, stimulates the conversion of the terminal element of the mammary glands. Due to the normalization of education dihydrotestosterone (main metabolite) has anti-androgenic activity. Antialdosteronovy effect contributes to the urinary tract.
Indications Prometrium 200 mg:
The drug is used for corrective therapy for endogenous progesterone deficiency.
Oral capsules using Prometrium:
• infertility due to insufficiency of the corpus luteum ovary
• irregular menstrual cycle due to anovulation, disorders of ovulation,
• breast disease (fibrocystic)
• premenstrual syndrome
• in combination with estrogen means is designated as a hormone replacement therapy in menopause syndrome.
Intravaginal use capsules Prometrium 200 mg:
• maintenance of the luteal phase of the menstrual cycle in preparation for assisted reproductive technologies (IVF, egg donation, etc.)
• maintenance of the luteal phase in the induced or spontaneous menstrual cycle,
• in combination with estrogen means is designated as a hormone replacement therapy in menopause syndrome,
• hormone replacement therapy in case of premature menopause
• infertility due to insufficiency of the corpus luteum ovary
• prevention of endometriosis, uterine fibroids,
• preventive treatment with the usual loss of pregnancy due to progesterone deficiency,
• Treatment of threatened abortion arising due to progesterone deficiency.
How to use Prometrium 200 mg:
Prometrium capsules orally. In case of insufficiency of progesterone in most cases appointed by 200-300 mg. Dose divided into two stages: in the morning and evening.
In case of insufficiency of the corpus luteum ovarian (menstrual irregularities, premenstrual tension syndrome, fibrocystic breast disease, premenopausal disorders, dysmenorrhea) Prometrium is taken from the 16 th and 25 th days of the menstrual cycle (10-12 days).
For hormone replacement therapy in combination with estrogen Prometrium appointed: in premenopausal women – 200 mg / day 10-12 days during the second phase of the cycle, menopause 100 mg per day continuously.
Prometrium capsules taken by mouth, not chewing. Wash down with water.
Application Prometrium capsules intravaginally (deep into the vagina). In the absence of ovarian (Or non-functioning ovaries, and egg donation) is prescribed in combination with estrogen by means of 100 mg per day in the vagina at night from 13th to 14 th day of the menstrual cycle. For 15-25-th day of the menstrual cycle increase the dose to 200 mg per day. Then, with a 26-day cycle to increase the dose to 100 mg / day every 7 days. In the case of pregnancy, the dose may be increased to 800 mg / day in 3 intravaginal administration. Dose of 800 mg per day is recommended to appoint within the next 60 days.
When vitro fertilization for the maintenance of luteal prescribe 400-800 mg per day vaginally. Administration of the drug prescribed daily injections of human chorionic gonadotropin and continued until 8 weeks of pregnancy. In what drug is given by indications (maximum – up to 37 weeks gestation).
In induced and spontaneous menstrual cycle, infertility due to luteal insufficiency prescribe 200-300 mg per day intravaginally with 17-day menstrual cycle 10 days. In the case of pregnancy, treatment is continued.
When threatened abortion or pre-emptive treatment is not the usual gestation due to progesterone deficiency appoint 400-800 mg per day vaginally. This dose is divided into 2 doses. Therapy was continued in the first and second trimester of pregnancy.
Side effects Prometrium 200 mg:
From the reproductive system: intermenstrual bleeding or spotting (rare).
The central nervous system: dizziness after 1-3 hours after taking Prometrium, drowsiness.
Can also be hypersensitivity reactions.
Contraindications Prometrium 200 mg:
• Bleeding from the genital tract of unknown origin,
• tendency to thrombosis (for oral)
• incomplete abortion,
• malignant disease of the reproductive organs and mammary glands (including the suspicion of the malignant process in these organs),
• porphyria,
• severe disorders of liver functions (only for oral use)
• allergic reactions to components of Prometrium.
Pregnancy Prometrium 200 mg:
Prometrium is not contraindicated during pregnancy. However, in the third trimester be used with caution because of the increased risk of disorders of liver function. Designate caution during breastfeeding.
Interaction with other drugs Prometrium 200 mg:
Prometrium potentiates the effects of hypotonic drugs, diuretics, anticoagulants, immunosuppressants. The drug can reduce the lactogenic action of oxytocin.
Overdose Prometrium 200 mg:
Symptoms of overdose may have symptoms characteristic of the side effects. Symptoms disappear spontaneously in the case of dose reduction Prometrium.
Product:
Capsules 100 mg – 30 tablets in a blister. Capsules 200 mg – 14 pieces in a blister. Capsule oval, with a shiny surface, yellowish in color. Inside the capsule – a homogeneous oily suspension white with no visible phase separation. Blister packed in a cardboard box.
Ingredients Prometrium 200 mg:
Active ingredient: natural micronized progesterone.
Additional ingredients: peanut butter, soy lecithin, glycerin, gelatin, titanium dioxide.
Extras:
Use with caution in patients with arterial hypertension and other cardiovascular system in chronic renal failure, epilepsy, asthma, depression, migraine, gipolipoproteinemii. Not assigned to contraceptive use. When you receive Prometrium caution when driving vehicles and lesson activities that require the speed of psycho-motor reactions and increased attention (because of possible dizziness and drowsiness).
Attention!
Before using Prometrium medication you should consult your doctor. This instruction is given a free transfer and is intended solely for information. For more information, please contact the manufacturer annotations.
